Protein A - Wikipedia
Protein A is a 42 kDa surface protein originally found in the cell wall of the bacteria Staphylococcus aureus. It is encoded by the spa gene and its regulation is controlled by DNA topology, cellular osmolarity, and a two-component system called ArlS-ArlR.
What is Protein A? - News-Medical.net
2019年2月26日 · Protein A is a 42KDa cell surface protein which is found on the cell walls of 90% of Staphylococcus aureus bacterial strains. It is encoded for by the polymorphic X-region of the SpA gene, and...
Protein A - an overview | ScienceDirect Topics
Protein A. Protein A is a multifunctional CWA protein that is both covalently anchored to peptidoglycan by sortase A and released into the extracellular milieu [50,75,76]. Protein A has five domains which recognize several different ligands, including tumour necrosis factor receptor-1 …
Mechanism of antibodies purification by protein A
2020年11月15日 · Protein A, a major cell wall component of Staphylococcus aureus, is one of the first immunoglobulin-binding proteins that is discovered about 80 years ago. However, a great deal of development in both purification methods and …
A comprehensive review on staphylococcal protein A (SpA): Its ...
Staphylococcal Protein A. The Staphylococcus aureus protein A (SpA) can be obtained through the culture of wild-type S. aureus and also as a recombinant protein in safe bacterial hosts.
Protein A superantigen: structure, engineering and molecular basis …
2019年12月31日 · Key among these is protein A, a B-cell superantigen capable of interacting with both antibody Fc and VH regions. Here, we review structural and molecular features of this important example of naturally occurring bacterial superantigens, as well as engineered variants and their application in biotechnology.
Mechanism of antibodies purification by protein A - PubMed
2020年11月15日 · Protein A, a major cell wall component of Staphylococcus aureus, is one of the first immunoglobulin-binding proteins that is discovered about 80 years ago. However, a great deal of development in both purification methods and …
Protein A - an overview | ScienceDirect Topics
Protein A is a 42-kDa protein found in the cell wall of Staphylococcus aureus that has a high affinity for the Fc region of immunoglobulins from various species. It is commonly used in immunoassays to detect and quantify antigens immobilized on a solid support. AI generated definition based on: Immunoassay, 1996
Spatial regulation of protein A in Staphylococcus aureus
Staphylococcal protein A (SpA) is well-known virulence factor that binds to host immunoglobulin and disrupts the host immune response (Forsgren & Sjöquist, 1966). We previously showed that SpA precursor containing the YSIRK/GXXS signal peptide engages the SecA-mediated secretion pathway ( Yu et al., 2018 ).
Protein A superantigen: structure, engineering and molecular …
2019年10月22日 · S. aureus protein A, a helical protein formed by five homologous domains, represents a fascinating case study of pathogen evolution. It mediates interactions with multiple host factors including both antibody Fc and V H regions.