Primary cilia as dynamic and diverse signalling hubs in ... - Nature
2023年4月18日 · Primary cilia, antenna-like sensory organelles protruding from the surface of most vertebrate cell types, are essential for regulating signalling pathways during development and adult homeostasis...
Cellular signalling by primary cilia in development, organ ... - Nature
2019年2月7日 · In this Review, we highlight central mechanisms by which primary cilia coordinate HH, G protein-coupled receptor, WNT, receptor tyrosine kinase and transforming growth factor-β (TGFβ)/bone ...
Primary Cilium | Learn Science at Scitable - Nature
Primary (non-motile) cilia of renal epithelial cells and connecting cilia of retinal photoreceptors are homologous structures. The primary cilium of renal epithelial cells are...
Signaling through the Primary Cilium - PMC - PubMed Central …
Primary cilia are particularly important during development, playing fundamental roles in embryonic patterning and organogenesis, with a suite of inherited developmental disorders known as the “ciliopathies” resulting from mutations in genes encoding cilia proteins.
The Primary Cilium as the Cell's Antenna: Signaling at a Sensory …
2006年8月4日 · The primary cilium has several characteristics that make it an ideal cellular location for sensing and transducing signals. It extends into the extracellular space, affording access to environmental signals.
Cellular signalling by primary cilia in development, organ …
Primary cilia emanate in a single copy from the centrosomal mother centriole (basal body) at the surface of most vertebrate cell types. Primary cilia possess a unique lipid and receptor composition and detect and convey extracellular cues to control cellular processes during development and in tissue homeostasis.
Primary Cilia: A Closer Look at the Antenna of Cells - Cell Press
2020年12月21日 · A recent study reports the three-dimensional structure of a primary cilium with unprecedented clarity. The results highlight the architectural differences with motile cilia and provoke a reassessment of the relationship between the ciliary cytoskeleton and microtubule-based transport in cilia.
Primary cilia shape hallmarks of health and aging - Cell Press
2023年5月1日 · Primary cilia are involved in six hallmarks of aging: altered intercellular communication, genomic instability, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction and cellular senescence, and stem cell exhaustion.
繊毛（immotile cilia ; primary cilia）では中心部の微小管が存在 せず 9＋0 構造をとる（図 1c）．微小管の基部には基底体（basal body）と呼ばれる器官が細胞内にあり，微小管の基部を形成
The molecular structure of mammalian primary cilia revealed by …
2020年9月28日 · Primary cilia are isolated from monolayers of mammalian cells in culture for cryo-ET analyses, revealing new features as well as how they differ from motile cilia.