The PI3K Pathway in Human Disease - PubMed
2017年8月10日 · Phosphoinositide 3-kinase (PI3K) activity is stimulated by diverse oncogenes and growth factor receptors, and elevated PI3K signaling is considered a hallmark of cancer.
Classes of phosphoinositide 3-kinases at a glance - PMC
The phosphoinositide 3-kinase (PI3K) family is important to nearly all aspects of cell and tissue biology and central to human cancer, diabetes and aging. PI3Ks are spatially regulated and multifunctional, and together, act at nearly all membranes ...
PI3K signalling: the path to discovery and understanding
2012年2月23日 · Phosphoinositide 3-kinases (PI3Ks) generate intracellular lipids that affect a range of cell biological phenomena. They phosphorylate the 3-OH group of inositol membrane lipids to modulate...
PI3K-Akt pathway: its functions and alterations in human cancer
Phosphatidylinositol-3-kinase (PI3K) is a lipid kinase and generates phosphatidylinositol-3,4,5-trisphosphate (PI(3, 4, 5)P3). PI(3, 4, 5)P3 is a second messenger essential for the translocation of Akt to the plasma membrane where it is phosphorylated and activated by phosphoinositide-dependent kina …
The PI3K Pathway in Human Disease - Cell Press
As a central hub for cellular signaling, PI3K is an important regulator of cellular growth and function. This Review focuses on its basic signaling mechanisms as well as its role in metabolism and immune function in the context of cancer.
The role of PI3Kγ in the immune system: new insights and ... - Nature
2022年3月23日 · This Review discusses the immunomodulatory properties of phosphoinositide 3-kinase-γ (PI3Kγ) in health and in the context of various diseases, ranging from cardiovascular disease to auto ...
Targeting the phosphoinositide 3-kinase (PI3K) pathway in cancer
The phosphoinositide 3-kinase (PI3K) pathway, a critical signal transduction system linking oncogenes and multiple receptor classes to many essential cellular functions, is perhaps the most commonly activated signaling pathway in human cancer.
PI3K isoforms in cell signalling and vesicle trafficking
2019年5月20日 · PI3Ks are a family of lipid kinases that phosphorylate intracellular inositol lipids to regulate signalling and intracellular vesicular traffic. Mammals have eight isoforms of PI3K, divided into...
PI3K Signaling in Cancer: Beyond AKT - PMC - PubMed Central …
Phosphoinositide 3-kinase (PI3K) signaling plays a central role in cellular physiology, coordinating insulin signaling during organismal growth and mediating critical cellular processes such as glucose homeostasis, protein synthesis, cell proliferation, and survival.
Phosphatidylinositol 3-Kinase, Growth Disorders, and Cancer
2018年11月22日 · Phosphatidylinositol 3-kinase (PI3K) is involved in multiple cell processes, including insulin signaling, cell growth, immunity, and brain development. It is activated in a wide variety of...
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