Functions of the Lyn tyrosine kinase in health and disease
2012年7月17日 · In B-CLL cells Lyn is present throughout the cytoplasm and not just localized to the plasma membrane as in normal B-cells. Further, they have substantial basal Lyn kinase activity that is un-responsive to IgM stimulation, unlike that seen in non-malignant cells.
Lyn and Fyn function as molecular switches that control ... - Nature
2017年8月15日 · Here we show that Lyn and Fyn control immune receptor signaling status. SHP-1 tyrosine 536 phosphorylation by Lyn activates the phosphatase promoting inhibitory signaling through the...
LYN kinase programs stromal fibroblasts to facilitate leukemic …
2023年3月10日 · Here, the authors show that LYN kinase is essential for the reprogramming of stromal cells towards a leukemia-supportive phenotype that facilitates disease progression.
Functions of the Lyn tyrosine kinase in health and disease
2012年7月17日 · In an analysis of primary AML cells, 76% had elevated Lyn kinase activity, while none had constitutive JAK2 activation; moreover, inhibition of Lyn activity (using genetic and small molecule inhibitors) in AML cell lines substantially decreased cell growth .
Functions of the Lyn tyrosine kinase in health and disease
2012年7月17日 · A protein called Lyn is one of these enzymes that regulate information transfer within cells to modulate cell growth, survival and movement. Depending on which type of cell and the source of the information input, Lyn can positively or …
Lyn kinase regulates egress of flaviviruses in autophagosome …
2020年10月15日 · Here, the authors show that Lyn is a critical host kinase for Dengue and Zika virus egress resulting in infectious virus progenies within autophagosome-derived vesicles, which might help the...
LYN Gene - GeneCards | LYN Protein | LYN Antibody
2024年10月2日 · LYN (LYN Proto-Oncogene, Src Family Tyrosine Kinase) is a Protein Coding gene. Diseases associated with LYN include Autoinflammatory Disease, Systemic, With Vasculitis and Dyskeratosis Congenita, Autosomal Dominant 6 .
Lyn Kinase Structure, Regulation, and Involvement in ... - MDPI
2022年12月20日 · The Lyn catalytic (kinase) domain is composed of 255 amino acid residues with a bilobal protein–tyrosine kinase fold that catalyzes the phosphorylation of the specific tyrosine residues of various immune receptors and effector proteins.
Lyn Tyrosine Kinase: Immunity - Cell Press
2004年12月2日 · Hematopoietic cells express two forms of lyn kinase differing by 21 amino acids in the amino terminus
The role of the tyrosine kinase Lyn in allergy and cancer
2021年3月1日 · The novel Lck/yes-related protein tyrosine kinase (Lyn) belongs to the Src kinase family (SFK) and plays a pivotal role in the pathogenesis of inflammation, tumor, and allergy. This signaling molecule is vital in the IgE/FcεRI signaling pathway that regulates allergy.