Interleukin 11 - Wikipedia
Interleukin 11 (IL-11 or adipogenesis inhibitory factor [5]) is a protein that in humans is encoded by the IL11 gene. [6] IL-11 is a cytokine that was first isolated in 1990 from bone marrow-derived fibrocyte-like stromal cells.
白细胞介素-11 - 百度百科
白细胞介素-11是 趋化因子 家族的一种 细胞因子 ，共发现了29个白细胞介素（可能为35个），分别命名为il-1---il29.功能复杂，成网络，复杂重叠。 中文名
Inhibition of IL-11 signalling extends mammalian healthspan and ...
2024年7月17日 · IL-11 is identified as a key regulator of ERK–AMPK–mTORC1 signalling, metabolism, inflammation and age-related disease and lifespan in mouse and human.
Inhibiting IL11: a novel approach to turning back the clock
2024年10月21日 · Recent advances have identified interleukin-11 (IL-11), a pro-inflammatory cytokine, as a key player in modulating aging pathways (such as ERK, AMPK, mTOR and JAK–STAT3). Studies have shown that IL-11 inhibition can lead to improved health span and lifespan in animal models, with potential applications in humans.
IL-11，纤维化疾病的真正元凶，被忽略的癌症潜力靶点 - 知乎
2023年2月13日 · 白细胞介素(IL)-11是一种基质细胞衍生的细胞因子，属于IL-6细胞因子超家族，由成骨细胞、滑膜细胞、成纤维细胞、软骨细胞、滋养细胞等多种类型的细胞分泌，后通过与IL-11R alpha及gp130受体结合并激活下游STAT3信…
Interleukin-11: Review of Molecular, Cell Biology, and Clinical …
1997年6月1日 · FIRST ISOLATED IN 1990, interleukin-11 (IL-11) has proven to be a fascinating cytokine with pleiotropic effects on multiple tissues. Initially characterize
Structural insights into IL-11-mediated signalling and human
2024年3月7日 · Here we solve the cryoEM structure of the IL-11 receptor recognition complex to discover how differences in gp130-binding interfaces may drive signalling outcomes.
Structures of the interleukin 11 signalling complex reveal gp130 ...
2023年11月20日 · Our results reveal the structural basis of IL-11 signalling, define the molecular mechanisms of an inhibitor, and advance understanding of gp130-containing receptor complexes, with potential ...
Hiding in Plain Sight: Interleukin-11 Emerges as a Master …
The IL-11 receptor is highly expressed on stromal, epithelial and polarized cells, where noncanonical IL-11 signaling drives the three pathologies common to all fibro-inflammatory diseases—myofibroblast activation, parenchymal cell dysfunction, and inflammation—while also inhibiting tissue regeneration.
血小板减少症之救星 ——IL-11 － 丁香通
2017年8月31日 · IL-11 是一种非糖化蛋白质, 不含有半胱氨酸, 分子量约 23kD, 由 179 个氨基酸组成，pH6.3，是造血微环境中一个多功能的调节因子。人类 IL-11 基因含 5 个外显子, 长度为 7kb, 染色体位点是 19q13.3～ 13.4 。 二、功能. IL-11 最主要的功能是单独或与其它细胞因子协同刺激 ...