Mechanotransduction by Hair Cells: Models, Molecules, and …
Mechanotransduction, the transformation of mechanical force into an electrical signal, allows living organisms to hear, register movement and gravity, detect touch, and sense changes in cell volume and shape. Hair cells in the inner ear are specialized mechanoreceptor cells that detect sound and head movement.
A bundle of mechanisms: Inner-ear hair-cell mechanotransduction
In the inner ear, the deflection of hair bundles, the sensory organelles of hair cells, activates mechanically-gated channels (MGCs). Hair bundles monitor the head’s orientation, its angular and linear acceleration, and detect sound.
Mechanotransduction by hair cells: models, molecules, and ... - PubMed
2009年10月2日 · Mechanotransduction, the transformation of mechanical force into an electrical signal, allows living organisms to hear, register movement and gravity, detect touch, and sense changes in cell volume and shape. Hair cells in the inner ear are specialized mechanoreceptor cells that detect sound and head movement.
Mechanotransduction in mammalian sensory hair cells
2022年5月1日 · Displacement of the hair bundle causes mechanotransduction channels to open. The morphology and organization of the hair bundle, as well as the properties and characteristics of the mechanotransduction process, differ between the different hair cell types in the auditory and vestibular systems.
Integrating the biophysical and molecular mechanisms of auditory hair ...
2011年11月1日 · Nature Communications - Hair cells of the inner ear transduce vibrations of the basilar membrane into electrical signals by a process known as mechanotransduction. Recent advances in genetic...
A Bundle of Mechanisms: Inner-Ear Hair-Cell Mechanotransduction
2019年1月17日 · What are the molecular underpinnings of hair-cell mechanotransduction? What are the pore forming domains of the MGCs? How are the molecules coupled and what is the specific function of each?
Mechanosensory hair cells express two molecularly distinct ...
In the organ of Corti of the mammalian cochlea (Fig. 1A) hair cells are the mechanosensory cells for the perception of sound. Mechanotransduction channels in hair cells are localized in their hair bundles, which consist of stereocilia that are organized in rows of decreasing heights (Fig. 1B) 1. In a healthy hair cell, deflection of the hair ...
Molecular Crux of Hair Cell Mechanotransduction Machinery
2020年8月5日 · Located in the inner ear, hair cells act as mechanoreceptors when sound waves deflect on hair bundles, thereby converting mechanical vibrations into electrical signals. Hair bundles incorporate three rows of ascending height stereocilia connected through tip links.
Mechanotransduction of the Hair Cell | SpringerLink
This book summarizes the emerging experimental evidence on hair-cell mechanotransduction, and covers hair’s cellular structure, biophysical properties, molecular components and functions. Auditory hair cells convert sound-induced vibration into electrical signals.
Hair-Cell Mechanotransduction and Cochlear Amplification
2005年11月3日 · Hair cells detect sounds with their mechanotransduction apparatus, which is only now being dissected molecularly. Signal detection is not the only role of this molecular network; amplification of low-amplitude signals by hair bundles seems to be universal in hair cells.