Cleavage of Type I Collagen by Fibroblast Activation Protein-α
2016年3月2日 · Our results demonstrate that FAP selectively cleaves type I collagen resulting in increased macrophage adhesion. Increased macrophage adhesion to FAP-cleaved collagen was not affected by inhibiting integrin-mediated interactions, but was abolished in macrophages lacking the class A scavenger receptor (SR-A/CD204).
Type-I collagen produced by distinct fibroblast lineages reveals ...
2021年12月10日 · Type I collagen (Col1) is the most abundant protein in mammals. Col1 contributes to 90% of the total organic component of bone matrix. However, the precise cellular origin and functional...
Chain alignment of collagen I deciphered using computationally
2020年1月6日 · Designed heterotrimers of collagen I, locked in three possible chain registers, enable structural and functional characterization of each permutation, leading to identification of the AAB ...
Collagenolysis-dependent DDR1 signalling dictates pancreatic …
2022年10月5日 · Cleaved and intact type I collagen have different effects on pancreatic ductal adenocarcinoma (PDAC), and remodelling of type I collagen—mediated through DDR1 signalling—is a prognostic ...
Type I Collagen: Structure, Synthesis, and Regulation
2002年1月1日 · The characteristic Type I collagen is the most abundant extracellular feature of fibrillar collagens is that they consist of a long protein of bones and is essential for bone strength. This continuous triple helix, which self-assembles into highly chapter first discusses the structure and biosynthesis of type organized fibrils.
Cleavage of Type I Collagen by Fibroblast Activation Protein ... - PubMed
2016年3月2日 · Our results demonstrate that FAP selectively cleaves type I collagen resulting in increased macrophage adhesion. Increased macrophage adhesion to FAP-cleaved collagen was not affected by inhibiting integrin-mediated interactions, but was abolished in macrophages lacking the class A scavenger receptor (SR-A/CD204).
Multifaceted collagen-DDR1 signaling in cancer - Cell Press
2023年9月12日 · A new study performed in pancreatic ductal adenocarcinoma (PDAC) shows that DDR1 activity is regulated by the cleavage state of COL I. Whereas COL I that has been cleaved by matrix metalloproteinases (MMPs) promotes DDR1 autophosphorylation, full length COL I induces DDR1 proteasomal degradation .
Immunoassays for Collagenase-Mediated Cleavage of Type I …
2010年1月1日 · This chapter describes the production and characterization of antibodies raised against neoepitopes in collagenase-cleaved collagen. It also details the development, validation, and use of immunoassays using such antibodies to measure specifically...
Effects of flexibility of the α2 chain of type I collagen on ...
2018年9月1日 · The abundant heterotrimeric type I collagen composed of two α1(I) chains and one α2(I) chain is efficiently cleaved by MMP-1 at a unique site in the triple helix, a process which may be initiated by local unfolding within the peptide chains.
Current Insights into Collagen Type I - MDPI
2021年8月9日 · This review aims to discuss Col-I, covering the structure, various sources of availability, native collagen synthesis, current extraction methods, physicochemical characteristics, applications in various fields, and biomarkers.