Anaplastic lymphoma kinase - Wikipedia
Anaplastic lymphoma kinase (ALK) also known as ALK tyrosine kinase receptor or CD246 (cluster of differentiation 246) is an enzyme that in humans is encoded by the ALK gene. [5] [6]
ALK Gene - GeneCards | ALK Protein | ALK Antibody
2024年10月1日 · Tocris Summary for ALK Gene. Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase (RTK) that was first identified in anaplastic large cell lymphoma (ALCL) as part …
ALK gene: MedlinePlus Genetics
The ALK gene provides instructions for making a protein called ALK receptor tyrosine kinase, which is part of a family of proteins called receptor tyrosine kinases (RTKs). Learn about this …
ALK and Lung Cancer - American Lung Association
2024年10月2日 · For some people, it gets turned back on and fuses, or joins, with another gene. This gene change is called an ALK fusion or ALK rearrangement and can cause cancer. When …
ALK Positive Lung Cancer: Life Expectancy, Survival, and More - Healthline
2021年1月27日 · The anaplastic lymphoma kinase (ALK) mutation is one of those gene changes. Knowing whether your cancer is ALK positive can help your doctor figure out which treatments …
Anaplastic Large Cell Lymphoma - StatPearls - NCBI Bookshelf
2023年7月3日 · Anaplastic lymphoma kinase positive (ALK+) anaplastic large cell lymphoma (ALCL) is a peripheral T-cell lymphoma (PTCL) that consists of characteristic large …
ALK-positive lung cancer: a moving target | Nature Cancer
2023年2月16日 · Anaplastic lymphoma kinase (ALK) is a potent oncogenic driver in lung cancer. ALK tyrosine kinase inhibitors yield significant benefit in patients with ALK fusion-positive (ALK …
Mechanism for the activation of the anaplastic lymphoma kinase ... - Nature
2021年11月24日 · Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase (RTK) that regulates important functions in the central nervous system 1, 2. The ALK gene is a hotspot for …
Anaplastic lymphoma kinase: role in cancer pathogenesis and …
In neither of these reports was the expression of TPM4–ALK independently confirmed using other methodologies (e.g., anti-ALK immunostaining, RT-PCR and/or FISH to identify the …
ALK‐rearrangement in non‐small‐cell lung cancer (NSCLC) - PMC
The ALK gene encodes a transmembrane tyrosine kinase receptor. ALK is physiologically expressed in the nervous system during embryogenesis, but its expression decreases …