抗体的结构 - 知乎 - 知乎专栏
在人体内，抗体可以分为IgG、IgM、IgA、IgD和IgE五种亚型，这五种抗体的基本结构类型相似，都是由4条多肽链构成，相互之间主要的差异点是重链（因此本小结也是对抗体Fc片段结构的描写）的结构不同，五种抗体亚型的重链对应的分别为γ、μ、α、δ和ε链。
抗体可变区CDR标注 - 在线工具 - 纽普生物 - NovoPro
对抗体可变区进行CDR和FR区域的标注；用户需要选择一种编号系统，编号方案（antibody numbering scheme）有：IMGT, Chothia, Kabat, Martin (扩展版Chothia)；标注方案（definition scheme）包括：Chothia, Kabat, IMGT及 Contact。
Antibody CDR annotation
Antibody CDR annotation. Find the CDRs and FRs in an protein sequence. If you want to numbering an antibody please visit Antibody Sequence Numbering. 1. Input a single protein (raw sequence): Full Length: 0. 2. Select a numbering scheme: IMGT Kabat Chothia Martin. 3.
IMGT Index
The Complementarity Determining Regions (CDR) and the Framework Regions (FR) are parts of the variable regions of the Immunoglobulin and T cell Receptor chains. The IMGT unique numbering for V-REGION [1] has allowed to redefine the limits of the Complementarity Determining Regions and Framework Regions, designated as CDR-IMGT and FR-IMGT ...
抗体结构 - 知乎 - 知乎专栏
可变区是抗体结合抗原的位置，其氨基酸的组成和排列决定抗体的抗原结合特异性。 可变区存在一些氨基酸能够高频变化组合的区域，这些区域称为超变区(hypervariable region，HVR)，超变区又称为互补决定区（complementarity-determining region, CDR），超变区决定了抗体的 ...
抗体CDR区序列分析：如何揭示其与抗原的特异性？ - 知乎
2023年8月25日 · 抗体cdr区序列分析是揭示抗体与抗原特异性结合的重要方法。通过计算和实验方法，我们可以深入了解cdr区的功能和序列多样性，并揭示抗体与抗原之间的特异性结合机制。
Complementarity Determining Region (CDR-IMGT) | SpringerLink
A Complementarity determining region (CDR-IMGT) is a loop region of a V-DOMAIN (Variable (V) Domain), delimited according to the IMGT unique numbering for V domain (Lefranc et al. 2003). There are three CDR-IMGT in a V-DOMAIN: CDR1-IMGT (loop BC), CDR2-IMGT (loop C′C″), and CDR3-IMGT (loop FG).
Antibody CDR amino acids underlying the functionality of …
2022年7月22日 · We found that antibodies recognize cognate protein antigens by forming key contacts involving a subset of aromatic CDR residue sidechains on the exposed CDR residue positions, and in...
Understanding the Significance and Implications of Antibody ... - PubMed
2018年10月16日 · An important prerequisite for antibody humanization requires standardized numbering methods to define precisely complementary determining regions (CDR), frameworks and residues from the light and heavy chains that affect the binding affinity and/or specificity of the antibody-antigen interaction.
Structural classification of CDR-H3 revisited: a lesson in …
2008年11月15日 · Among the six complementarity-determining regions (CDRs) in the variable domains of an antibody, the third CDR of the heavy chain (CDR-H3), which lies in the center of the antigen-binding site, plays a particularly important role in antigen recognition.
- 某些结果已被删除