Cyclins are proteins that control the progression of a cell through the cell cycle by activating cyclin-dependent kinases (CDK). [1] Etymology. Cyclins were originally discovered by R. Timothy Hunt in 1982 while studying the cell cycle of sea urchins. [2][3]
2023年7月19日 — An introduction to cyclins. The accurate transmission of genetic information from a cell to a daughter cell is ensured by the tight regulation of the four stages of the cell cycle. The stages of...
Two groups of proteins, called cyclins and cyclin-dependent kinases (Cdks), are responsible for the progress of the cell through the various checkpoints. The levels of the four cyclin proteins fluctuate throughout the cell cycle in a predictable pattern.
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Cyclins are a group of stress-sensitive proteins in controlling cell death and survival in DNA damage response. The B-type cyclin, i.e., cyclin B1, is an essential cell cycle component in the regulation of transition from G2 to M phase [127–130].
Cyclins are a family of proteins that have no enzymatic activity of their own but activate CDKs by binding to them. CDKs must also be in a particular phosphorylation state — with some sites...
Cell cycle progression is regulated in part by the sequential activity of various cyclins. The cyclins are regulatory subunits that bind, activate and provide substrate specificity for their catalytic partner serine-threonine kinases, collectively called cyclin-dependent kinases (Cdks) (reviewed in …