Targeted chemotherapy for subcutaneous and orthotopic non …
2018年12月14日 · Intriguingly, cRGD-PS-Dox effectively suppressed the growth of A549 lung tumors in both subcutaneous and orthotopic models with minimal adverse effects at a Dox dose of 12 mg/kg, leading to...
A549 Xenograft Model - Altogen Labs
The A549 CDX model is the highly utilized xenograft lung cancer model for studying standard of care and novel therapeutics (i.e. erlotinib, gefitinib, lapatinib, paclitaxel) due to overexpression of EGFR and HER-2.
A549 Xenograft Model - Melior Discovery
The A549 xenograft model utilizes a well-characterized cell line first cultured in 1972 from an explanted lung tumor of a 58-year-old caucasian male. A549 cells are one of the most popular cell lines used in the study of NSCLC for over 50 years, and implanting these established cells into mice offers a more realistic environment for testing ...
Improvement of subcutaneous CDX model of lung cancer using A549 …
2020年5月25日 · The purpose of the study was to create a subcutaneous cell line-derived xenograft (CDX) model of lung cancer using the human lung cancer cells A459 and to compare results of subcutaneous injections of a cell suspension with different numbers of cells in two groups of animals.
Targeted chemotherapy for subcutaneous and orthotopic non …
2018年12月14日 · The exceptional therapeutic benefits of cRGD-PS-Dox in the treatment of subcutaneous lung tumor models encouraged us to further assess its targetability and antitumor effects in orthotopic human A549 lung tumor xenografts in mice, which was established by implanting bioluminescent A549-Luc cancer cells into the lungs of nude mice (n = 6). The ...
A549 in-silico 1.0: A first computational model to simulate cell
2021年6月22日 · This first A549 in-silico cell model opens up a deeper insight and understanding of possible ion channel interactions in tumor development and progression, and is a valuable tool for simulating altered ion channel function in lung cancer electrophysiology.
Targeting STAT3 signaling overcomes gefitinib resistance in
2021年5月31日 · In summary, our research shows that targeting STAT3 may be an effective treatment for gefitinib-resistant NSCLC. In order to explore the resistance of gefitinib in lung cancer, we built gefitinib...
A549 cell - Wikipedia
A549 cells are widely used as a type II pulmonary epithelial cell model for drug metabolism and as a transfection host. [4] When grown for a sufficiently long time in cell culture, A549 cells may begin to differentiate , as signaled by the presence of multilamellar bodies .
Pressure increases PD-L1 expression in A549 lung ... - Nature
2022年4月28日 · In this study, we investigated if elevated pressure could affect αROR1-CAR T cell-mediated cytotoxicity in lung cancer cell line A549 and whether immune checkpoint PD-L1 was involved. Our results...
Single-cell transcriptome analysis reveals dynamic changes of the ...
2023年12月5日 · The in vitro A549 cells, and A549 xenografts in nude mouse, were two commonly used models for anti-cancer drug discovery. However, the biological and molecular characteristics of these two classic models, and also the dynamic transcriptome changes after dacomitinib exposure remains elusive.