These findings highlight the dual roles of antioxidants in cancer. Their impact depends on cancer type, stage, and genetic ...

Ago2 differentially regulates oncogenic and tumor-suppressive miRNAs in cancer cells. This discrepancy suggests a secondary event regulating Ago2/miRNA action in a context-dependent manner. We show ...

After being informed of a potential microduplication in Figure 1D, the journal contacted the authors for clarification. The ...

Remnants of transposable elements (TEs) are widely expressed throughout mammalian embryo development. Originally infesting our genomes as selfish elements and acting as a source of genome instability, ...

Each journal is staffed by professional editors who work in collaboration with one another and our international Editorial Advisory Boards of leading scientists. Please feel free to contact any of the ...

imageimageHow ion transport proteins affect tumorigenesis remains poorly understood. Here, comprehensive pan-cancer data mining combined with in silico and functional analyses uncovers a catalogue of ...

Plants produce a wide diversity of compounds. Broadly, these are separated into primary metabolites, which are necessary for ...

N6-methyladenosine (m 6 A) exerts many of its regulatory effects on eukaryotic mRNAs by recruiting cytoplasmic YT521-B homology-domain family (YTHDF) proteins. Here, we show that in Arabidopsis ...

imageimageThere are no cellular or molecular biomarkers diagnostic of myalgic encephalomyelitis (also known as chronic fatigue syndrome [ME/CFS]). We find hundreds of blood-based traits are different, ...

This month's cover highlights the article Palmitoylated Importin α Regulates Mitotic Spindle Orientation Through Interaction with NuMA by Patrick James Sutton, Natalie Mosqueda and Christopher ...

Ependymal cells are multiciliated glial cells lining the ventricles of the mammalian brain. Their differentiation from progenitor cells involves cell enlargement and progresses through centriole ...

imageimageHow spindle-tethering complexes read the cell polarity axis during asymmetric cell division and couple spindle attachment to mitotic progression remains poorly understood. Here, the scaffold ...