Rationale Asthma is characterized by type 2 (T2) inflammation, small airway dysfunction (SAD), mucus plugging, and remodeling. Airway remodeling is poorly responsive to current therapies, contributing ...

Background The lower airway microbiota in patients with chronic obstructive pulmonary disease (COPD) are likely altered compared with the microbiota in healthy individuals. Information on how the ...

In the 1990s, metered dose inhalers (MDIs) containing chlorofluorocarbons were replaced with dry-powder inhalers (DPIs) and MDIs containing hydrofluorocarbons (HFCs). While HFCs are not ozone ...

Background Little is known about the impact of exacerbations on COPD progression or whether inhaled corticosteroid (ICS) use and blood eosinophil count (BEC) affect progression. We aimed to assess ...

Background Antimicrobial resistance (AMR) is a growing global health crisis and is particularly relevant to people living ...

Background People with recurrent or drug-resistant TB require long courses of intramuscular injections. We evaluate a novel system in which patient-nominated lay carers were trained to deliver ...

Objectives Infliximab, an anti-TNF agent, is used to treat sarcoidosis that does not respond to corticosteroids or second-line agents. The efficacy of other anti-TNF agents, non-TNF biologics and ...

Background Newborn bloodspot screening (NBS) for cystic fibrosis (CF) was introduced across the UK in 2007 but the impact on clinical outcomes and health inequalities for children with CF is unclear.

Background There is emerging evidence suggesting a link between ambient heat exposure and chronic obstructive pulmonary disease (COPD) hospitalisations. Individual and contextual characteristics can ...

Chronic cough (CC) is common, predominantly affecting middle-aged females. Sufferers experience significantly impaired quality of life (QoL). Cough is associated with increased healthcare costs.

Asthma is the most common chronic respiratory disease in the UK; however, the misdiagnosis rate is substantial. The lack of consistency in national guidelines and the paucity of data on the ...

Rationale Advance care planning (ACP) is uncommon in patients with chronic obstructive pulmonary disease (COPD). Objectives To assess whether a nurse-led ACP-intervention can improve quality of ...