2018 Meetings Abstracts: Fifth AACR-IASLC International Joint Conference: Lung Cancer Translational Science from the Bench to the Clinic January 8–11, 2018; San Diego, CA Proceedings: AACR Annual ...

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Abstract. Glioblastoma (WHO grade IV glioma) is the most common malignant primary brain tumor in adults. Survival has remained largely static for decades, despite significant efforts to develop new ...

Increased exon skipping, particularly affecting proteasome-related transcripts, was mediated by elevated serine/arginine-rich splicing factor 6 (SRSF6) levels in T-cell acute lymphoblastic leukemia.

Abstract. In mammals, the histone methyltransferase KMT2C is one of the major regulators of gene expression and is one of the most commonly lost epigenetic regulators across all cancers. Studies in ...

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HBV-induced upregulation of HSPA8 promotes hepatocarcinogenesis by suppressing ferroptosis and stimulating HBV replication, identifying HSPA8 as a potential therapeutic target in liver cancer.

DKK1 is demonstrated to induce immunosuppressive polarization of macrophages, promoting tumor immune evasion in gastric cancer. The data showcase the potential of targeting DKK1, alone and in ...

An antibody–drug conjugate (ADC) class that combines a novel self-immolative T moiety and the topoisomerase I inhibitor exatecan displays higher therapeutic indices to overcome intrinsic or induced ...

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A computational approach shows cryptic peptides as an abundant class of epitopes in different tumor samples. This approach can potentially be used to elucidate complete HLA-I immunopeptidomes and aid ...