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《自然》(20250220出版)一周论文导读
研究者使用冷冻电子显微镜、AlphaFold24和基于分子动力学的改进的综合方法,在大多数区域展示了亚纳米分辨率的apoB100的结构。该结构由一个大的球状N端结构域和一个约61纳米长的连续两亲β片组成,该β片像带一样包裹着LDL颗粒。准对称分布在β带两侧的是9个战略性的链间插入物,它们延伸到脂质表面,通过远程相互作用的网络提供额外的结构支持。
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