When glutamate is too high and GABA levels are too low, as is the case with fibromyalgia and ME/CFS, symptoms like hyperalgesia (heightened sensitivity to pain), anxiety, restlessness, brain fog, ...

Uncontrolled glutamate release in the brain Date: April 22, 2025 Source: Ruhr-University Bochum Summary: Upon energy restriction, an unusual release of the neurotransmitter glutamate can be observed.

Discover how the brain's most abundant neurotransmitter, glutamate, is revolutionizing psychiatry and offering new hope for depression, bipolar disorder, and more.

Glutamate excites neurons, creating the electrical activity essential for normal brain function. This excitatory transmission occurs through several specialized receptors, including NMDA, AMPA ...

Glutamate gating of AMPA-subtype iGluRs at physiological temperatures Ionotropic glutamate receptors (iGluRs) are tetrameric ligand-gated ion channels that mediate most excitatory neurotransmission.

The presence of glutamate reprogrammes the metabolism of macrophages, and these consequently begin to secrete a growth factor that leads to an increase in hepatocyte production. In other words, a ...

Dietary glutamate supplementation may simply be recommended in the future after liver extirpation, and also to reduce liver damage caused by cirrhosis, which is common in patients with poor diet ...

Glutamate cysteine ligase (GCL) deficiency is a rare autosomal recessive trait that compromises production of glutathione, a critical redox buffer and enzymatic cofactor. Patients have markedly ...

5-HTP: Your body converts 5-HTP (5-hydroxytryptophan) into serotonin (5-hydroxytryptamine), and serotonin can enhance GABA activity, which may affect glutamate activity. Glutamate is the precursor to ...

Kombu is a type of giant kelp. It's naturally high in glutamic acid which, when cooked, becomes glutamate. (Getty Images: K3)Soon after, Dr Ikeda developed a seasoning by binding glutamate with ...

Monosodium glutamate, or MSG — a food additive that is often found in Asian cuisine — has had something of a negative reputation over the last 60 years. Some food experts insist that's unfair.