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21 小时
北京大学苗蕾团队开发一种高效低毒可吸入式mRNA LNP用于慢性肺病治疗
利用此非炎症LNP装载编码NR1D1(一种时钟基因)的mRNA,能够有效治疗幼大鼠支气管肺发育不良和小鼠特发性肺纤维化。经过制备工艺优化该LNP具有良好的雾化及冻干稳定性,能够经雾化吸入将 ...
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