A cure for chronic hepatitis B requires eliminating or permanently silencing covalently closed circular DNA (cccDNA). A pivotal target of this approach is the hepatitis B virus (HBV) X protein (HBx), ...

To better understand the potential health threats and underlying visual pathways of long-term light at night (LAN) exposure, we adopted a widely accepted diurnal animal model tree shrew (Tupaia ...

Developing oral biologics has long been a holy grail of protein engineering. Traditional antibodies are large and unstable in the presence of gastrointestinal proteases. Here, we present a strategy to ...

Greening immediately after etiolated-seedling’s emergence from the soil is critical for plants to initiate their autotrophic life cycle through photosynthesis. The greening process relies on a complex ...

As AI tools become increasingly prevalent in workplaces, understanding the social dynamics of AI adoption is crucial. Through four experiments with over 4,400 participants, we reveal a social penalty ...

The study of the role of disease mutation and selecting tauopathy-specific pathways was supported by the NIH under Grant Number R01AG05605. The study of the minimal prion design and seeding of tau was ...

Regional high-resolution climate projections are crucial for many applications, such as agriculture, hydrology, and natural hazard risk assessment. Dynamical downscaling, the state-of-the-art method ...

Cognitive function emerges from cortical network dynamics and is often impaired in neuropsychiatric disorders like epilepsy. Physics and information theory suggest that brain networks operate ...

Organic semiconductors (OSCs) are pivotal for next-generation flexible electronics but are limited by an intrinsic trade-off between mobility and stability. We introduce adaptive surface doping (ASD), ...

In 2024, one of seven students worldwide had their education disrupted by the types of extreme weather made worse by climate change, according to a report from UNICEF (3). In Vietnam, for example, ...

Vibrio cholerae, known for its pathogenicity in humans, is most commonly a marine microbe that forms biofilms on chitin particles, which it can consume as a source of carbon and nitrogen. Upon ...

Religious leaders shape the attitudes and beliefs of their congregations. In a nationally representative sample of U.S. religious leaders (N = 1,600), the majority of which were of a Christian faith, ...