Background Todd's paresis is a transient focal weakness of the hand, arm or leg which follows partial seizure activity within that limb. This was first described by Robert Bentley Todd in 1849. The ...

2 NIHR Biomedical Research Centre, Guy's & St. Thomas’ NHS Foundation Trust and King's College London, London, UK 3 Farr Institute of Health Informatics, University College London, London, UK 4 ...

Traumatic brain injury (TBI) leads to increased rates of dementia, including Alzheimer’s disease. The mechanisms by which trauma can trigger neurodegeneration are increasingly understood. For example, ...

University of Iowa, The Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa, USA Objective: The objective of the Predict-HD study is to use genetic, neurobiological and refined clinical ...

Department of Social Medicine, University of Bristol, Canynge Hall, Bristol, UK Professor N J Scolding, University of Bristol Institute of Clinical Neurosciences, Frenchay Hospital, Bristol BS16 1LE, ...

The brain is in a constant state of dynamic change, for example switching between cognitive and behavioural tasks, and between wakefulness and sleep. The brains of people with epilepsy have additional ...

Apathy is increasingly recognised as a common behavioural syndrome in psychiatric disorders, but it is conceptually ill defined. The aim of this study was to examine the concept of apathy as it is ...

Correspondence to Dr Michael Benatar, Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida, USA; MBenatar{at}med.miami.edu Notwithstanding the challenges, it is ...

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder affecting the upper and lower motor neurons. A key clinical feature of ALS is the absence of accurate, early-stage ...

Objectives To determine current epidemiology and clinical characteristics of cerebrospinal fluid (CSF) shunt surgery, including revisions. Methods A retrospective, multicentre, registry-based study ...

Parkinson’s disease (PD) is an incurable and progressive neurological disorder leading to deleterious motor and non-motor consequences. Presently, no pharmacological agents can prevent PD evolution or ...

Background Subthalamic nucleus deep brain stimulation (STN-DBS) for Parkinson’s disease (PD) improves quality of life (QoL), motor and non-motor symptoms (NMS). However, in previous studies, 43%–49% ...