Ketamine may work in other ways in the brain, too. Some nerve cells in the brain involved in mood use a chemical called glutamate to communicate with each other. The nerve cells need glutamate ...

Background: Two current theories regarding the neuroscientific bases of mood disorders involve alterations in glutamatergic neurotransmission and excessive activation of inflammatory pathways. We ...

Glutamate stimulates the brain, while GABA calms it down ... One study shows that those suffering from depression, epilepsy, post-traumatic stress disorder (PTSD), and chronic pain—all medical ...

New research sheds light on how ketamine affects the brain by targeting a specific NMDA receptor subtype, GluN1-2B-2D.

Long-term depression (LTD) encompasses a family of synaptic plasticity mechanisms that can be triggered by the synaptic or pharmacological activation of glutamate receptors — in particular ...

Glutamate stimulates the brain ... One study shows that those suffering from depression, epilepsy, post-traumatic stress disorder (PTSD), and chronic pain—all medical conditions that involve ...

At least 21 million adults in the U.S. have experienced depression. And, while oral antidepressant medications are a common treatment, they don't work for everyone. Now, the Food and Drug ...

These sleep loss changes are recovered by sleep. Sleep genes are enriched for synaptic shaping cellular components controlling glutamate synapse phenotype, overlap with autism risk genes, and are ...

Spravato targets the neurotransmitter glutamate; however, the mechanism by which esketamine exerts its antidepressant ... This is due to the risks for serious adverse outcomes resulting from sedation, ...

A nasal spray that contains esketamine — a potent derivative of ketamine — can now be taken on its own to treat adults with ...

A one-time nasal spray has been approved by the Food and Drug Administration as a standalone treatment for depression. The drug made by Johnson & Johnson under ... The one-time treatment targets ...