In biochemical and cellular studies, Circle Pharma’s cyclin A/B RxL inhibitors have been shown to potently and selectively disrupt the protein-to-protein interaction between cyclins A and B and ...

In biochemical and cellular studies, Circle Pharma’s cyclin A/B RxL inhibitors have been shown to potently and selectively disrupt the protein-to-protein interaction between cyclins A and B and their ...

Since, the discovery in the seventies and eighties of the core machinery regulating the eukaroytic cell cycle, the cyclin-dependent kinases (cdks) and cyclins, the cell-cycle field has grown ...

Carbonic anhydrases (CAs) are widespread enzymes in bacteria, archaea and eukaryotes, and catalyze a crucially important physiological reaction: the hydration of carbon dioxide to bicarbonate and ...

Laboratory Research on Biological Systems and Geomatics, Mustapha Stambouli University of Mascara, Mascara 29001, Algeria ...

Executed global exclusive development and commercialization license agreement with Novartis to advance VAV1-directed molecular glue degraders including MRT-6160 for immune-related conditions; $150M ...

Of those genes, hepatocyte nuclear factor-4α (HNF4α) was one key transcription factor. Inhibitory RNA and pharmacological inhibition of HNF4α demonstrated antineoplastic activity in vitro and in vivo ...