Background Chronic inflammation and elevated reactive oxygen species are key contributors to hepatocellular carcinoma (HCC) ...

Background Liver metastasis is a major cause of mortality in patients with colorectal cancer (CRC). Understanding how CRC cells influence the formation of hepatic premetastatic niches (PMNs) is ...

Randomised controlled trials (RCTs) have shown that computer-aided detection (CADe) can significantly improve adenoma detection rates (ADRs). In contrast, implementation studies did not show ADR ...

A high adenoma detection rate (ADR) is vital for effective colorectal cancer (CRC) screening, but evidence suggests limited additional benefit beyond a certain threshold. In a pooled analysis of five ...

Lin Y, Pu S, Wang J et al. Pancreatic STAT5 activation promotes KrasG12D-induced and inflammation-induced acinar-to-ductal metaplasia and pancreatic cancer. Gut 2024;73:1831–3. A magnified version of ...

Background Non-variceal upper gastrointestinal bleeding (NVUGIB) remains a major cause of morbidity and mortality. Rebleeding rates following endoscopic treatment can reach up to 25% within 72 hours ...

The British Society of Gastroenterology’s (BSG) latest 5-year national guideline for inflammatory bowel disease (IBD)1 has recently completed. This adjunct commentary to the guideline contains the ...

Introduction There are approximately 15,000 new diagnoses of oesophageal and gastric cancer every year, in the UK (Cancer Research UK, 2022). Timely detection of cancer remains a key marker in ...

The gut microbiota is now considered as one of the key elements contributing to the regulation of host health. Virtually all our body sites are colonised by microbes suggesting different types of ...

Most colon cancers are assumed to have a premalignant adenomatous polyp phase, therefore colonoscopic detection and polypectomy provides the opportunity for cancer prevention. Some patients who have ...

Background and aims: This study evaluates the long-term safety of infliximab in patients with inflammatory bowel disease (IBD) treated with the drug over a 14-year period. Methods: The medical records ...

Background Type 2 diabetes mellitus (T2DM) characterized by glucose intolerance accounts for approximately 90% of all diabetic patients worldwide. Although studies have monitored the gut microbiota ...