Main text Please take note of the following when preparing your manuscript for PNAS: Do not include statements of novelty or priority. Avoid laboratory jargon. Use correct chemical names. Specify ...

A cure for chronic hepatitis B requires eliminating or permanently silencing covalently closed circular DNA (cccDNA). A pivotal target of this approach is the hepatitis B virus (HBV) X protein (HBx), ...

We thank Jun Chen for providing wdr5 mutant, Anming Meng for providing rnaseh1 MO, Dengli Hong for providing 2×HBD, and Yu Sun for assistance during the experimental process. This work was supported ...

Resolving the complex evolutionary history of polyploid species like octoploid strawberry is challenging due to the number of potential progenitors and the potential for hybridization events within ...

HIV-1 infection remains incurable because of the long-lasting HIV-1-infected latency cells residing in the host. Current treatment strategies are unable to completely eliminate the virus latent ...

Organic semiconductors (OSCs) are pivotal for next-generation flexible electronics but are limited by an intrinsic trade-off between mobility and stability. We introduce adaptive surface doping (ASD), ...

Many cities seek to alleviate extreme heat via planting trees. However, the cooling achieved by such programs is debated because previous analyses address scales much smaller than the whole-city scale ...

The Cry proteins are pore-forming toxins produced by various strains of Bt to aid the bacteria in killing and growing on insects that happen to consume bacterial spores loaded with these crystalline ...

The discovery of Lophiostroma leizunia Jeon sp. nov., a 480-My-old phosphatic stromatoporoid sponge from South China, revolutionizes our understanding of early reef ecosystems and biomineralization.

Chronic inflammatory skin disorders affect millions worldwide. Our study reveals a role for acetylcholine (ACh), a molecule typically associated with neuronal signaling, in regulating skin health. We ...

Efforts to anticipate and adapt to future climate can benefit from historical experiences. We examine agroclimatic conditions over the past 50 y for five major crops around the world. Most regions ...

A huge challenge for the application of few-layer two-dimensional (2D) materials in next-generation integrated circuits is synthesizing wafer-scale films with a strictly consistent number of layers ...