University of Iowa, The Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa, USA Objective: The objective of the Predict-HD study is to use genetic, neurobiological and refined clinical ...

Traumatic brain injury (TBI) leads to increased rates of dementia, including Alzheimer’s disease. The mechanisms by which trauma can trigger neurodegeneration are increasingly understood. For example, ...

The brain is in a constant state of dynamic change, for example switching between cognitive and behavioural tasks, and between wakefulness and sleep. The brains of people with epilepsy have additional ...

Apathy is increasingly recognised as a common behavioural syndrome in psychiatric disorders, but it is conceptually ill defined. The aim of this study was to examine the concept of apathy as it is ...

Correspondence to Dr Michael Benatar, Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida, USA; MBenatar{at}med.miami.edu Notwithstanding the challenges, it is ...

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder affecting the upper and lower motor neurons. A key clinical feature of ALS is the absence of accurate, early-stage ...

Correspondence to Professor Jan D Lünemann, Department of Neurology with Institute of Translational Neurology, University Hospital Münster and Univerisity of Münster, Faculty of Medicine, Munster, ...

Objectives To determine current epidemiology and clinical characteristics of cerebrospinal fluid (CSF) shunt surgery, including revisions. Methods A retrospective, multicentre, registry-based study ...

Background Cognitive and behavioural dysfunction may occur in people with motor neuron disease (MND), with some studies suggesting an association with the C9ORF72 repeat expansion. Their onset and ...

Parkinson’s disease (PD) is an incurable and progressive neurological disorder leading to deleterious motor and non-motor consequences. Presently, no pharmacological agents can prevent PD evolution or ...

7 Department of Neurology, Queen Elizabeth Hospital, Edgbaston, Birmingham, UK 8 Department of Neurology, King's College Hospital and King's College School of Medicine, London, UK Correspondence to Dr ...

Background Subthalamic nucleus deep brain stimulation (STN-DBS) for Parkinson’s disease (PD) improves quality of life (QoL), motor and non-motor symptoms (NMS). However, in previous studies, 43%–49% ...