Nearly 150 years ago, scientists discovered that specialized blood cells serve a vital role in immune system protection ...

The term idiopathic neutropenia describes a benign disorder ... disease entities on the basis of the underlying pathogenetic mechanisms: first, the primary autoimmune neutropenia mediated by ...

Using blood progenitor cell lines that can be induced to undergo maturation towards fully functional neutrophils, we are elucidating the molecular mechanisms that control neutrophil differentiation ...

However, the actual molecular mechanism of the anti-inflammatory ... Antithrombin stimulates CLEC1A on human neutrophil cells ...

Determining enzyme mechanisms includes determining their kinetic and thermodynamic properties. Myeloperoxidase (MPO) plays an important role in the innate immune response of human neutrophils and ...

Antithrombin strongly regulated human neutrophils by stimulating the identified ... However, the actual molecular mechanism of anti-inflammatory effect of antithrombin was completely unknown.

[89] The beneficial effect of the treatment is associated with a reduction in serum levels of IL-1β and TNF-α and, occasionally, with amelioration of neutropenia substantiating the important ...