Ketamine may work in other ways in the brain, too. Some nerve cells in the brain involved in mood use a chemical called glutamate to communicate with each other. The nerve cells need glutamate ...

Glutamate stimulates the brain ... One study shows that those suffering from depression, epilepsy, post-traumatic stress disorder (PTSD), and chronic pain—all medical conditions that involve ...

Long-term depression (LTD) encompasses a family of synaptic plasticity mechanisms that can be triggered by the synaptic or pharmacological activation of glutamate receptors — in particular ...

The drug acts as a non-selective, non-competitive antagonist of the NMDA receptor and works by targeting glutamate in the ... in average Montgomery-Åsberg Depression Rating Scale (MADRS) total ...

We have investigated the role of mitochondrial calcium buffering in excitotoxic cell death. Glutamate acts at NMDA receptors in cultured rat forebrain neurons to increase the intracellular free ...