The Cleveland Guardians (40-48) and the Houston Astros (55-35) open a 3-game series Monday at Daikin Park in Houston. First pitch is scheduled for 8:10 p.m. ET. Let's analyze BetMGM Sportsbook's MLB odds around the Guardians vs. Astros odds and make our expert MLB picks and predictions for the best bets.

The Astros blasted the Dodgers 18-1 in Friday's series opener, and Houston clinched the series victory with a 6-4 win as moderate underdogs (+145) Saturday as the Over (9) cashed. Houston has picked up 5 victories in the past 6 meetings in this series,

Against three MVPs and a nasty crowd of hateful boo birds, the walking-wounded, quad A Astros came into Los Angeles and dominated the Dodgers, taking three straight. They outscored the boys in blue 29-6 in the series.

Christian Walker, Yainer Diaz and Jose Altuve each homered, Ryan Gusto threw six strong innings, and the Houston Astros beat the Los Angeles Dodgers 5-1 on Sunday to complete their first three-game sweep at Dodger Stadium since May 9-11,

The Astros sweep the Dodgers in Los Angeles, the Pirates turn good history into bad, the Guardians blew it in the ninth and more from the weekend's MLB action.

Yainer Diaz hit a home run and Framber Valdez recovered from a wobbly start as the visiting Houston Astros followed a blowout victory Friday with a 6-4 win over the Los Angeles Dodgers on Saturday.

Pregame analysis and predictions of the Cleveland Guardians vs. Houston Astros MLB game to be played on July 7, 2025 on ESPN.

But ahead of the series against the Cleveland Guardians, the Astros announced a roster move involving Walker. The Astros placed Walker on the paternity list and called up outfielder Kennedy Corona from Triple-A Sugar Land.